Acute scrotum caused by an extraspermatic venous thrombosis associated with G20210A prothrombin gene mutation in a pediatric patient: A case report

Erika Llorens de Knecht, Santiago Guadarrama, Claudia Quintian Schwieters, Anna Bujons Tur


Thrombosis of an extraspermatic blood vessel has been reported to be an unusual cause of acute scrotum. We describe the case of a 7-year-old boy who presented with an acute painful left scrotal swelling. Imaging demonstrated a heterogeneous left scrotal mass, which was surgically resected. The anatomopathologic study revealed a thrombosed vascular structure. Three months later, another extraspermatic venous thrombosis occurred and was also resected. A complete thrombophilia study was done. A G20210A prothrombin gene heterozygous mutation was identified as the cause of the thrombotic event. A venous thrombosis should be considered as a possible cause of acute scrotum in European Caucasian patients, due to its increased prevalence. We reviewed the G20210A prothrombin gene mutation, which is associated with thrombosis.


Extraspermatic; thrombosis; G20210A gene; thrombophilia

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